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Histofix®-Safe

Item no.: 146444
0

Secure biopsy fixation starts here

€88.00 net
Your PLUS customer savings €4.40 net
Packaging unit: 50 PC
In stock

Guaranteed usable: 30.10.2026

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No formaldehyde exposure

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Intuitive & easy to use

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Easy to store & transport

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Recyclable disposable product

Safe & Comfortable Biopsy Handling

The Histofix®-Safe system from PanReac AppliChem ITW Reagents is a state-of-the-art container for the safe handling and fixation of biopsies in clinical diagnostics. It is specifically designed to protect medical personnel from exposure to carcinogenic formaldehyde solutions, which are commonly used in pathology and histology. Regular contact with formaldehyde can pose significant health risks, including respiratory irritation, allergic skin reactions, and an increased risk of tumors in the nasal and throat area. Its closed system minimizes the risk of vapor or droplet release, which can occur with comparable systems, thereby effectively protecting against inhalation and skin contact.

A bidirectional valve enables the safe transfer of formaldehyde solution from a filled to an empty container without releasing any vapors. The integrated grid with safety cap ensures that even sticky samples can be securely placed and retrieved without coming into contact with formalin. Compliant with Regulation (EU) 2017/746 on in vitro diagnostics (IVDR), Histofix®-Safe offers maximum reliability and safety in daily work. Available in various sizes, this innovative sample container combines optimal occupational protection with easy handling, making it an indispensable tool for safe and efficient biopsy processing.

Product Details 

  • Histofix®-Safe – modern fixation system for biopsies
  • Ready-to-use preservative for clinical diagnostics
  • Contains 4% formaldehyde solution, buffered with sodium phosphate (pH 7) and stabilized with methanol
  • Enables safe and comfortable handling of tissue samples in daily medical practice
  • Closed system for fixation and shipment of small histological samples
  • Minimizes the risk of formaldehyde exposure for medical personnel
  • Compliant with Regulation (EU) 2017/746 on in vitro diagnostics (IVDR)
  • Bidirectional valve provides outstanding safety and usability advantages over conventional systems
  • Fixative solution is transferred from the stock container to the sample container by pressure
  • Safety grid with cap effectively prevents vapor release
  • The grid allows placement and retrieval of even sticky samples without direct contact with formalin
  • Ideal combination of user protection and simple operation
  • Available in multiple size variants

"The formaldehyde solution carries certain health risks for the user, according to Regulation (EU) No. 605/2014 as it has been classified as carcinogenic and mutagenic substance."

 

Formaldehyde – A Toxic Substance in Daily Medical Work 

Formaldehyde is a colourless gas with a pungent odour, commonly used in aqueous solution as formaldehyde solution. Due to its disinfectant and preservative properties, it is frequently used in the medical field for the fixation of tissue samples. Despite its usefulness, formaldehyde poses significant health risks to medical personnel.

Even at low concentrations, formaldehyde can irritate the mucous membranes of the eyes and respiratory tract, causing symptoms such as burning eyes, sore throat, and coughing. Repeated skin contact with formaldehyde can also lead to allergic reactions, including rashes and dermatitis. Some individuals may develop sensitization, which can trigger stronger reactions upon subsequent exposure. Formaldehyde is classified as carcinogenic to humans. Repeated exposure often leads to chronic inflammation, which can create a breeding ground for the development of cancer cells. Tumours can particularly develop in the nasal and throat area, where airborne formaldehyde concentrations are highest.

Medical personnel who regularly work with formaldehyde solution – for example, in pathology or during sample collection in clinical practice – are at increased risk. Inhalation of formaldehyde is especially dangerous, as even small concentrations can irritate the respiratory tract and have long-term carcinogenic effects.

 

Save 10% on Histofix® Safe Today

For precise results, Histofix Safe is the perfect choice. This ready-to-use solution delivers consistently high fixation quality while enhancing safety in the laboratory. Its smart safety cap minimises formaldehyde exposure, ensuring maximum protection for users and optimal sample preservation. 

Limited Time Offer. Enter the promo code histofix-10 at checkout to get 10% off your entire Histofix Safe order. Don’t miss out – the discount is available only while the promotion lasts.

 

Product Benefits at a Glance

  • No user exposure to formaldehyde.
  • Sample grid enables easy biopsy collection.
  • Bi-directional valve avoids formaldehyde backflow and prevents sample/biopsy transfer to the formaldehyde reservoir container
  • Burr next to the sample grid facilitates easy biopsy deposition.
  • Proven leak-tightness and stability during pneumatic-tube transport.

 

Maximum Safety for Everyone

From tissue collection to laboratory analysis, safety is the top priority. 

Unlike other fixation solutions that mainly protect clinic and laboratory staff, Histofix Safe ensures every step – from sample collection to lab processing – is controlled and secure when handling formalin. 

In daily medical work, this means no direct contact with fumes, no open containers, and no unnecessary exposure. Sample containers are securely sealed, safely transported, and handled in the lab without risk. This preserves valuable tissue while reliably protecting the entire team, from assistants to pathologists, from formaldehyde exposure. 

Histofix Safe is more than just a fixation solution – it is a comprehensive safety concept that combines precision with health protection.

Sample Fixation Made Simple and Safe

Step 1
Keep the empty container at the top and the container with the formaldehyde at the bottom.
Step 2
Unscrew the empty container and remove the sealing plug by pressing the tab towards the burr. IMPORTANT: When unscrewing, hold the device at the magenta thread, never at the lower container.
Step 3
Place the sample on the grid of the stopper, using tweezers and the central burr of the stopper. Screw the empty container back on, making sure that it is tightly closed. Turn the assembly to have the container with the formaldehyde liquid on top.
Step 4
Press the upper container until all the liquid flows into the lower container through the bidirectional valve. The sample will be immersed in the formaldehyde, starting the fixation process. Hold the assembly in this position. The sample is ready to be transported in formaldehyde to the laboratory.
Step 5
Turn the Histofix®-Safe container upside down, leaving the sample container and formaldehyde on top.
Step 6
Press the upper vessel to pass all theformaldehyde through the two-way valve into the lower vessel.
Step 7
Unscrew the top empty container to recover the sample. IMPORTANT: When unscrewing, hold the device at the magenta thread, never at the lower container.
Step 8
Use tweezers to collect the sample retained on the grid. The sample is now ready to be processed.
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FAQs

 

How is a Biopsy Fixed?

A biopsy is fixed with formaldehyde or formalin to prevent autolytic changes. Samples should be placed immediately after collection into 10% buffered formalin. 

 

What is a Histological Examination?

Histology is a branch of biology/medicine that studies the composition, structure, and properties of the tissues of living organisms. It is closely related to microscopic anatomy, as it examines not only tissues but also the internal structures of cells and other organelles. Histology also integrates aspects of biochemistry and cytology. 

 

What is the Difference Between Formaldehyde and Formalin?

Formaldehyde is a colourless, water-soluble gas with a pungent odor. Formalin is a liquid solution of formaldehyde in water. A saturated solution contains about 37% formaldehyde by weight. 

 

Is Formaldehyde Carcinogenic?

Formaldehyde was classified as a category 1B carcinogen in 2014. This classification came into effect under EU Regulation (No. 605/2014).

Product Identification
  • Manufacturer: PanReac AppliChem ITW Reagents
  • Manufacturer article number: 2584620962
  • Item no.: 146444
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Histofix®-Safe
€88.00 net
Your PLUS customer savings €4.40 net